Combining CBD and Evil Bone Water

Evil Bone Water and Silverdome Garden's CBD

Today, we’re delving into one of his renowned creations, Evil Bone Water, and exploring its exceptional benefits in enhancing the effectiveness of CBD cream when combined. This groundbreaking solution can potentially change the permeability of the skin, providing a more targeted and efficient approach to pain relief.

The Power of Combining Evil Bone Water with CBD Cream

Merging the capabilities of Evil Bone Water with CBD cream unlocks the full potential of CBD, providing targeted and efficient pain relief. Evil Bone Water prepares the skin for better absorption of the CBD, allowing it to penetrate deeper and offer pain relief for up to 2-3 hours longer.

This unique combination ensures that the CBD is utilized to its fullest extent, maximizing benefits for users.

Understanding the Role of Alcohol in Topicals

Alcohol-based topicals, like ethanol, are widely used in topical applications and are generally safe, even under heavy-use conditions. Ethanol decreases skin oil and lowers the skin barrier function, making the membrane more permeable. This allows for better penetration of other herbs and ingredients, such as CBD, when used in combination with Evil Bone Water.

The Art of Using Liniments and Salves

Alcohol-based liniments, such as Evil Bone Water, are known for their quicker absorption speed compared to oil-based topicals. The alcohol content in these liniments allows the active ingredients to penetrate the skin rapidly and reach the affected muscles or joints more effectively. This leads to faster relief from pain and discomfort. The trade-off is that this volatility causes it to evaporate and dry quickly off the skin.

On the other hand, oil-based salves tend to be slower to absorb and act more as a time-release mechanism. They create a barrier on the skin, gradually releasing the active ingredients over time. While both types of topicals can be beneficial, combining them, you get the best of both.

How CBD and Evil Bone Water Complement Each Other

Topical CBD and Evil Bone Water are both known for their pain-relieving properties, albeit through different mechanisms.

Sensory neurons

Sensory neurons in our skin contain pain receptors that help us feel pain. These receptors can be turned on or off by natural substances in the skin, like histamine. The way we perceive pain is also influenced by our brain and brain stem. The most common type of pain receptor found in the skin is known as transient receptor potential (TRP) channels.

San Qi

Evil Bone Water, an ancient Chinese remedy, contains an ingredient called Panax notoginseng or “san qi,” which has been used for centuries to treat pain. The active components in Panax notoginseng are compounds called ginsenosides, which can be absorbed into the skin when applied topically.

Research has shown that one particular ginsenoside, called Rg1, can help reduce pain by blocking specific pain receptors (TRPV1 channels) and decreasing inflammation. This is achieved by reducing the production of a molecule called PGE2, which is known to cause inflammation. Another study found that ginsenosides might directly block these pain receptors in sensory neurons, further contributing to their pain-relieving effects.

Panax notoginseng has been used safely for centuries in traditional medicine, making it a reliable ingredient for remedies like Evil Bone Water. By targeting specific pain receptors and reducing inflammation, the ginsenosides in Evil Bone Water can provide relief from pain and discomfort, offering a natural option for managing pain.


Topical CBD (cannabidiol) is a non-psychoactive compound derived from the cannabis plant, which has gained popularity for its potential anti-inflammatory and analgesic effects. When applied topically, CBD interacts with cannabinoid receptors (CB1 and CB2) in the skin, which are part of the endocannabinoid system. This system plays a key role in regulating pain and inflammation. By activating these receptors, CBD can help reduce inflammation and alleviate pain at the site of application (1).

Together is Better

Using CBD and Evil Bone Water together offers a comprehensive approach to pain relief by targeting different types of transient receptor potential (TRP) channels found in the skin. While CBD interacts with the endocannabinoid system, reducing inflammation and alleviating pain through the activation of CB1 and CB2 receptors, Evil Bone Water, which contains ginsenosides from Panax notoginseng, works by directly blocking TRPV1 channels in sensory neurons. This combined action of CBD and Evil Bone Water effectively addresses multiple pain pathways, providing enhanced relief from various types of pain and discomfort. By targeting different aspects of the pain response through TRP channels, this combination offers a powerful, synergistic approach to pain management that harnesses the benefits of both natural remedies.

Step-by-Step Instructions for Combining CBD and Evil Bone Water

  • Clean the affected area: Make sure the area where you want to apply the mixture is clean and free from dirt or debris.
  • Apply Evil Bone Water: Gently massage a small amount of Evil Bone Water onto the skin, covering the entire affected area.
  • Wait for the Evil Bone Water to be absorbed by the skin. This should take approximately 1-2 minutes.
  • Apply CBD cream: Once the Evil Bone Water has dried, apply a layer of CBD cream to the same area. Be sure to cover the entire region previously treated with Evil Bone Water.
  • Massage gently: Using your fingertips, gently massage the CBD cream into the skin, allowing it to penetrate the skin and work in harmony with the Evil Bone Water.
  • Repeat as needed: For optimal results, follow this process 2-3 times a day, or as recommended by your healthcare practitioner.


The combination of Evil Bone Water and CBD cream offers a powerful and synergistic approach to pain relief, harnessing the benefits of both components to provide targeted, efficient, and long-lasting relief. By understanding the role of alcohol-based topicals and the art of using liniments and salves, users can benefit from the complementary mechanisms of CBD and Evil Bone Water. This innovative treatment has the potential to revolutionize pain management and improve countless lives.


Hammell, D.C., Zhang, L.P., Ma, F., Abshire, S.M., McIlwrath, S.L., Stinchcomb, A.L., & Westlund, K.N. (2016). Transdermal cannabidiol reduces inflammation and pain-related behaviors in a rat model of arthritis. European Journal of Pain, 20(6), 936-948. doi: 10.1002/ejp.818

Y Kimura, M Sumiyoshi, M Sakanaka
Effects of ginsenoside Rb1 on skin changes
J Biomed Biotechnol (2012), 10.1155/2012/946242
View PDF Google Scholar

J Huang, L Qiu, L Ding, S Wang, J Wang, Q Zhu, et al.
Ginsenoside Rb1 and paeniflorin inhibit transient receptor potential vanilloid 1 activated IL-8 and PGE2 production in a human keratinocyte cell line HaCaT
Int Immunopharmacol, 10 (2010), pp. 1279-1283

Buy Evil Bone Water & CBD Products Today!

Evil Bone Water (Zheng Gu Shui) is a Chinese topical medicinal hand-crafted with only empirical grade herbal ingredients in an approved facility.

Experience the perfect fusion of pain relief and skincare with Silverdome Garden CBD Body Butter. We chose this product for its unique whipped texture, allowing easy application without the typical challenges of hard-to-apply CBD creams.